Conclusion: HCV associated OLP responded to DDAs irrespective of the genotype corresponding to a reduction in escudier score. Clinically refractory lichen planus resolved with DAAs treatment. Sustained virological response was observed in all patients irrespective of the genotype OLP was associated with.There was no worsening of lichen planus in any of the treated patients.
Results: Most common genotype associated with OLP was 3(65%) followed by 1(25%) and 4(15%).In our sample the other genotypes were not seen. The patient response were assessed before and after treatment using escudier scoring system. Out of eighteen, ten were males with a mean age of 64.
Eighteen patients with HCV-related OLP received Sofosbuvir with ribavirin for 24 weeks. Genotyping was done using genotype specific core primers in nested polymerase chain reaction, NS5B sequencing and 5’ non coding region based PCR restriction fragment length polymorphism. Methods: Lichen Planus refractory to conventional steroid treatment was considered as an oral manifestation of HCV and it was confirmed by anti-HCV by ELISA (third generation). The study was done to assess the various genotypes linked with hepatitis C associated OLP. The genotypes vary in pathogenicity and response to direct-acting antivirals (DAAs). Various genotypes may be associated with OLP. Objectives: Oral Lichen Planus (OLP) is one of the extraneous manifestation of hepatitis C infection. PP 0001 The genotypic association of Hepatitis C associated Oral lichen planus and its response to direct acting antivirals
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